The Best South America Multi-Country Holidays for 2026
South America is made for epic journeys. One day you’re exploring ancient Incan ruins in Peru, the next you’re sipping Malbec in Argentina or standing beneath the thunderous Iguazu Falls between Brazil and Argentina. The sheer diversity of landscapes, cultures and experiences makes multi-country travel one of the best ways to explore the continent.
Here are some of our best South America multi-country tours and why they deserve a place on your travel bucket list.
1. Peru, Bolivia & Chile: The Ultimate Andes Adventure
Best for:
Culture lovers, photographers and adventurous travellers.
This route is one of the most rewarding ways to experience the heart of the Andes. Starting in Peru, travellers can explore Lima’s food scene, Cusco’s colonial charm and the iconic ruins of Machu Picchu before crossing into Bolivia to discover Lake Titicaca and the surreal Uyuni Salt Flats. Chile provides the perfect finale with the dramatic Atacama Desert.
Our 22 -day multi-country trip combes slow travel with immersive local experiences in Peru and Chile and Bolivia, especially through sustainable lodges and remote landscapes.
Highlights:
- Machu Picchu and the Sacred Valley
- Lake Titicaca cultural experiences
- Uyuni Salt Flats photography tours
- Stargazing in Chile’s Atacama Desert
- Boutique eco-lodges and community-led tourism
Take a look at our 22-day epic multi-country holiday through Peru, Bolivia and Chile. (from £6,990pp)
2. Ecuador, Galapagos and Colombia Adventure: A Multi-Country Journey Through South America’s Most Diverse Landscapes
Best for:
Those looking to combine wildlife, time in the sea and amazing cultures.
Few South America itineraries combine wildlife, culture, beaches and adventure quite like an Ecuador, Galapagos and Colombia tour. From the volcanic landscapes of the Galapagos Islands to Colombia’s colourful Caribbean cities and coffee regions, this style of multi-country journey delivers an incredible variety of experiences in one seamless trip.
Our 21-day Ecuador, Galapagos and Colombia Adventure itinerary is designed for travellers seeking immersive experiences, sustainable tourism and a balance between adventure and comfort. The trip combines active travel, wildlife encounters with boutique accommodation and memorable experiences.
Highlights:
- Wildlife encounters
- Colonial architecture
- Cloud forests and volcanoes
- Coffee culture
- Adventure activities
Combine these three amazing destinations on our 21 day multi-country tour through Ecuador, Galapagos and Colombia (from £7,700pp)
3. Peru, Ecuador & The Galapagos Meets Ancient Civilisations
Best for:
Wildlife enthusiasts and luxury adventurers.
Combining Ecuador’s Galapagos Islands with Peru’s archaeological treasures creates an unforgettable contrast between wildlife and history. Our 22-day tailor-made tour focusses on island-hopping, responsible cruising and conservation-led travel experiences.
Highlights:
- Colonial Quito
- Sacred Valley and Machu Picchu
- Peruvian gastronomy in Lima
- Snorkeling, hiking and sustainable cruises
Looking for your next family multi-country holiday to South America? Take a look at our 22-day Peru, Ecuador and Galapagos Adventure, and speak to our experts about your dates. (From £5,950pp)
4. Patagonia Across Chile & Argentina
Best for:
Hikers, nature lovers and active travellers.
Patagonia is one of the world’s great wilderness regions, spanning both Chile and Argentina. Trek through Torres del Paine National Park, witness glaciers in El Calafate and cruise through dramatic fjords.
Our Chile and Argentina multi-country adventure-focused itineraries place strong emphasis on outdoor activities such as trekking, kayaking and remote lodge stays.
Highlights:
- Torres del Paine National Park
- Perito Moreno Glacier
- Hiking and wildlife excursions
- Scenic overland crossings
- Luxury and wilderness lodges
We have a range of tailor-made multi-country tours through Patagonia, take a look and speak to our experts with your wish list and dates. (From £4,185pp)
5. The Grand South America Circuit
Best for:
Bucket-list travellers and sabbaticals
For those with more time, a longer multi-country journey allows you to experience the true scale and diversity of South America. Our “Ultimate South America Sabbatical” spans 55- days and combines Peru, Bolivia, Chile, Brazil and beyond into one immersive adventure.
Highlights:
- Amazon rainforest experiences
- Incan heritage sites
- Salt flats and deserts
- Patagonia landscapes
- Rio de Janeiro and Brazilian culture
- Wildlife encounters across multiple ecosystems
Take a look at our 55-day multi-country South America odyssey, and our other longer sabbatical and retirements trips.
Why Multi-Country Tours Work So Well in South America
South America is enormous, and planning logistics independently can quickly become overwhelming. Travel Differently specialises in tailor-made itineraries rather than rigid group tours, which allows travellers to combine countries and experiences more flexibly. For entry advise into South America read more here.
Our multi-country tailor-made private tours:
- Handle internal flights and private transfers
- Provide expert local guides
- Balance iconic highlights with lesser-known experiences
- Include sustainable and community-focused tourism
- Customise trips around your pace and interests
Final thoughts
The best South America multi-country tours combine iconic sights with authentic experiences that go beyond standard tourist routes. Whether you want to hike through Patagonia, explore ancient Andean cultures or cruise around the Galapagos Islands, combining multiple countries gives you a richer understanding of the continent’s diversity.
Our multi-country holidays to South America offer sustainable tourism and slower, more meaningful journeys. For travellers looking to experience the continent in depth rather than simply ticking off landmarks, a thoughtfully designed multi-country tour remains one of the most rewarding ways to travel South America. Contact our travel experts to start planning your tailor-made multi-country tour to South America.
Why Book With Travel Differently
Passionate and experienced
- Each member of the team has over a decade of experience in the industry
- Our 5* client reviews reflect our service & standards
- We are a fully independent & owner-run tour operator
- Our holidays include full financial protection & ATOL coverage
- We are destination experts, ensuring authentic & reliable advice
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Tailor-made and Personal
- No two trips are the same, our holidays are 100% bespoke
- We design personal, genuine cultural connections & experiences
- From planning to travel, you’ll have one dedicated point of contact
- Our support is available around the clock during your holiday
- We take care of the details, so you don’t have to