The Best South America Multi-Country Holidays for 2026
South America is made for epic journeys. One day you’re exploring ancient Incan ruins in Peru, the next you’re sipping Malbec in Argentina or standing beneath the thunderous Iguazu Falls between Brazil and Argentina. The sheer diversity of landscapes, cultures and experiences makes multi-country travel one of the best ways to explore the continent.
Our top multi-country South America routes for 2026 include the Peru–Bolivia–Chile Andes circuit, the wildlife-focused Ecuador–Galapagos–Colombia journey, and Patagonia across Chile and Argentina — with tailor-made trips starting from £4,185 per person.
Here are some of our best South America multi-country tours and why they deserve a place on your travel bucket list.
Written by Sam, Travel Differently founder and South America specialist
Last updated 22nd September 2026
South America Multi-Country Holidays: At a Glance
| Route | Duration | From price | Best for |
| Peru, Bolivia & Chile: Ultimate Andes Adventure | 22 days | £6,990pp | Culture lovers, photographers, adventurous travellers |
| Ecuador, Galapagos & Colombia Adventure | 21 days | £7,700pp | Wildlife, culture and beaches combined |
| Peru, Ecuador & The Galapagos | 22 days | £5,950pp | Wildlife enthusiasts and luxury adventurers |
| Patagonia Across Chile & Argentina | Varies | £4,185pp | Hikers, nature lovers, active guests |
| The Grand South America Circuit | 55 days | £17,800pp | Bucket-list travel, sabbaticals, retirement trips, school summer holidays |
1. Peru, Bolivia & Chile: The Ultimate Andes Adventure
Best for:
Culture lovers, photographers and adventurous travellers.
This route is one of the most rewarding ways to experience the heart of the Andes. Starting in Peru, travellers can explore Lima’s food scene, Cusco’s colonial charm and the iconic ruins of Machu Picchu before crossing into Bolivia to discover Lake Titicaca and the surreal Uyuni Salt Flats. Chile provides the perfect finale with the dramatic Atacama Desert.
Our 22 -day multi-country trip combines slow travel with immersive local experiences in Peru, Chile and Bolivia, especially through sustainable lodges and remote landscapes.
Highlights:
- Machu Picchu and the Sacred Valley
- Lake Titicaca cultural experiences
- Uyuni Salt Flats photography tours
- Stargazing in Chile’s Atacama Desert
- Boutique eco-lodges and community-led tourism
Take a look at our 22-day epic multi-country holiday through Peru, Bolivia and Chile. (from £6,990pp)
2. Ecuador, Galapagos and Colombia Adventure: A Multi-Country Journey Through South America’s Most Diverse Landscapes
Best for:
Those looking to combine wildlife, time in the sea and amazing cultures.
Few South America itineraries combine wildlife, culture, beaches and adventure quite like an Ecuador, Galapagos and Colombia tour. From the volcanic landscapes of the Galapagos Islands to Colombia’s colourful Caribbean cities and coffee regions, this style of multi-country journey delivers an incredible variety of experiences in one seamless trip.
Our 21-day Ecuador, Galapagos and Colombia Adventure itinerary is designed for travellers seeking immersive experiences, sustainable tourism and a balance between adventure and comfort. The trip combines active travel, wildlife encounters with boutique accommodation and memorable experiences.
Highlights:
- Wildlife encounters
- Colonial architecture
- Cloud forests and volcanoes
- Coffee culture
- Adventure activities
Sam, our founder and Galapagos specialist, says: “This is the route I recommend most for couples or families who can’t decide between wildlife and culture — you genuinely don’t have to choose. Waking up in the Galapagos one week and wandering Cartagena’s old town the next is one of the most dramatic contrasts you can build into a single trip.”
Combine these three amazing destinations on our 21 day multi-country tour through Ecuador, Galapagos and Colombia (from £7,700pp)
3. Peru, Ecuador & The Galapagos Meets Ancient Civilisations
Best for:
Wildlife enthusiasts and luxury adventurers.
Combining Ecuador’s Galapagos Islands with Peru’s archaeological treasures creates an unforgettable contrast between wildlife and history. Our 22-day tailor-made tour focusses on island-hopping, responsible cruising and conservation-led travel experiences.
Highlights:
- Colonial Quito
- Sacred Valley and Machu Picchu
- Peruvian gastronomy in Lima
- Snorkeling, hiking and sustainable cruises
Sam, our founder and Peru specialist, says: “Machu Picchu and the Galapagos are both once-in-a-lifetime experiences on their own — combining them in one trip means you’re not choosing between culture and wildlife, you’re getting both at their absolute best.”
Looking for your next family multi-country holiday to South America? Take a look at our 22-day Peru, Ecuador and Galapagos Adventure, and speak to our experts about your dates. (From £5,950pp)
4. Patagonia Across Chile & Argentina
Best for:
Hikers, nature lovers and active travellers.
Patagonia is one of the world’s great wilderness regions, spanning both Chile and Argentina. Trek through Torres del Paine National Park, witness glaciers in El Calafate and cruise through dramatic fjords.
Our Chile and Argentina multi-country adventure-focused itineraries place strong emphasis on outdoor activities such as trekking, kayaking and remote lodge stays.
Highlights:
- Torres del Paine National Park
- Perito Moreno Glacier
- Hiking and wildlife excursions
- Scenic overland crossings
- Luxury and wilderness lodges
We have a range of tailor-made multi-country tours through Patagonia, take a look and speak to our experts with your wish list and dates. (From £4,185pp)
5. The Grand South America Circuit
Best for:
Bucket-list travellers and sabbaticals
For those with more time, a longer multi-country journey allows you to experience the true scale and diversity of South America. Our “Ultimate South America Sabbatical” spans 55- days and combines Peru, Bolivia, Chile, Brazil and beyond into one immersive adventure.
Highlights:
- Amazon rainforest experiences
- Incan heritage sites
- Salt flats and deserts
- Patagonia landscapes
- Rio de Janeiro and Brazilian culture
- Wildlife encounters across multiple ecosystems
Sinead, our Latin America and wildlife specialist, says: “This is the trip I design for guests who’ve said ‘we don’t know when we’ll be back, so let’s not miss anything.’ Fifty-five days sounds enormous until you’re actually out there — then it barely feels like enough.”
Take a look at our 55-day multi-country South America odyssey (from £17,800pp) and our other longer sabbatical and retirement trips.
Why Multi-Country Tours Work So Well in South America
South America is enormous, and planning logistics independently can quickly become overwhelming. Travel Differently specialises in tailor-made itineraries rather than rigid group tours, which allows travellers to combine countries and experiences more flexibly. For entry advice into South America read more here.
Our multi-country tailor-made private tours:
- Handle internal flights and private transfers
- Provide expert local guides
- Balance iconic highlights with lesser-known experiences
- Include sustainable and community-focused tourism
- Customise trips around your pace and interests
Frequently Asked Questions
Most of our tailor-made itineraries combine 2–3 countries, such as Peru, Bolivia and Chile, though longer trips like our 55-day Grand South America Circuit can combine 5 or more countries and ecosystems in one journey.
Most multi-country routes run 21–22 days to properly cover 2–3 countries without rushing. Shorter combinations are possible, but longer trips of a month or more allow for a genuinely immersive, unrushed pace.
Combining countries into one tailor-made itinerary is often more efficient than booking separately, since internal flights, transfers and accommodation are planned together, reducing dead time and duplicated costs.
The Peru, Ecuador and Galapagos route is a strong first-time choice, combining iconic history (Machu Picchu) with extraordinary wildlife (the Galapagos) in one well-paced 22-day journey.
Yes — every itinerary here is a starting point rather than a fixed package. We can weight a trip more heavily toward wildlife, active adventure, culture or luxury depending on what matters most to you.
Final thoughts
The best South America multi-country tours combine iconic sights with authentic experiences that go beyond standard tourist routes. Whether you want to hike through Patagonia, explore ancient Andean cultures or cruise around the Galapagos Islands, combining multiple countries gives you a richer understanding of the continent’s diversity.
Our multi-country holidays to South America offer sustainable tourism and slower, more meaningful journeys. For travellers looking to experience the continent in depth rather than simply ticking off landmarks, a thoughtfully designed multi-country tour remains one of the most rewarding ways to travel South America. Contact our travel experts to start planning your tailor-made multi-country tour to South America.
Why Book With Travel Differently
Passionate and experienced
- Each member of the team has over a decade of experience in the industry
- Our 5* client reviews reflect our service & standards
- We are a fully independent & owner-run tour operator
- Our holidays include full financial protection & ATOL coverage
- We are destination experts, ensuring authentic & reliable advice
Committed and Responsible
Tailor-made and Personal
- No two trips are the same, our holidays are 100% bespoke
- We design personal, genuine cultural connections & experiences
- From planning to travel, you’ll have one dedicated point of contact
- Our support is available around the clock during your holiday
- We take care of the details, so you don’t have to